Best Supplements to Support Your Body While on GLP-1 Medications

Introduction

GLP-1 medications help with weight loss by suppressing appetite, often leading to a significant reduction in food intake. While this can be beneficial for managing weight, it may also result in nutrient deficiencies, fatigue, and digestive discomfort. To ensure optimal health while on these medications, incorporating key supplements can help fill nutritional gaps, maintain energy levels, and support overall well-being. By proactively addressing these potential deficiencies, you can sustain your weight loss progress while feeling strong and healthy.

1. Protein for Muscle Preservation

One of the biggest concerns for individuals using GLP-1 medications is muscle loss due to reduced protein intake. Since these medications can significantly decrease hunger cues, many people naturally consume less protein, which is essential for muscle maintenance and metabolic health. Losing muscle mass can slow down metabolism, making long-term weight management more challenging.

To prevent this, supplementing with a high-quality protein source is recommended. Protein powders can be an easy and effective way to meet daily protein needs, especially for those who struggle to eat enough through whole foods.

Best options:
✔ Whey isolate for fast absorption and muscle recovery
✔ Plant-based protein for those with dairy sensitivities
✔ Collagen peptides to support joint, skin, and muscle health

Recommended intake: Aim for 1.0–1.2g of protein per kg of body weight daily to support muscle retention and overall metabolic function.

2. B Vitamins for Energy & Metabolism

Many people on GLP-1 medications report feeling fatigued or sluggish. Since reduced food intake can lead to lower levels of essential B vitamins, supplementing with a high-quality B-complex can support:

✔ Energy production – B vitamins help convert food into energy, preventing fatigue.
✔ Nerve function – Adequate levels of B12 and B6 support brain and nervous system health.
✔ Metabolism – B vitamins play a crucial role in maintaining a healthy metabolism and red blood cell production.

Best options: Choose a B-complex supplement with methylated B vitamins for better absorption, especially if you have the MTHFR (methylenetetrahydrofolate) gene mutation, which can affect how your body processes folate and B12.

3. Electrolytes for Hydration

GLP-1 medications can sometimes lead to nausea, diarrhea, or decreased water intake, which may cause electrolyte imbalances. This can result in headaches, dizziness, muscle cramps, and fatigue. Proper hydration and electrolyte balance are essential for overall health and energy levels.

To maintain hydration and support electrolyte balance, focus on replenishing key minerals such as:
💧 Magnesium – Supports muscle function, sleep, and relaxation.
💧 Potassium – Helps regulate blood pressure and prevent muscle cramps.
💧 Sodium – Essential for fluid balance, especially for those experiencing reduced appetite and water intake.

Best options: Use electrolyte powders, mineral drops, or natural sources like coconut water, bone broth, or potassium-rich foods (e.g., avocados and bananas).

4. Probiotics for Gut Health

Some GLP-1 users experience digestive issues such as constipation, bloating, or diarrhea due to changes in gut motility. A healthy gut microbiome plays a critical role in digestion, immune function, and even weight regulation. Adding probiotics can help balance gut bacteria and improve digestive health.

Best options: Look for a multi-strain probiotic that includes Lactobacillus and Bifidobacterium species, which have been shown to support digestion and gut balance. Additionally, incorporating prebiotic fiber (from foods like asparagus, onions, and flaxseeds) can help nourish beneficial gut bacteria.

Final Thoughts

Taking a proactive approach to supplementation while on GLP-1 medications can enhance your weight loss journey, prevent nutritional deficiencies, and support overall well-being. Whether it’s maintaining muscle mass with protein, boosting energy with B vitamins, staying hydrated with electrolytes, or improving gut health with probiotics, the right supplements can help you feel your best.

For high-quality, practitioner-recommended supplements, visit Ample’s Fullscript Dispensary, where you can find trusted, professional-grade products tailored to your health needs.

Need personalized guidance? Ample Health & Wellness can help create a customized supplement plan to support your weight loss and wellness goals.

References

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• Schwingshackl, L., & Hoffmann, G. (2013). Long-term effects of low-fat diets on blood lipids. European Journal of Nutrition, 52(5), 857-871.
• Slavin, J. (2013). Fiber and prebiotics: mechanisms and health benefits. Nutrients, 5(4), 1417-1435.
• Thomas, D. T., Erdman, K. A., & Burke, L. M. (2016). Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic Performance. Journal of the Academy of Nutrition and Dietetics, 116(3), 501-528.