Probiotics Might Be the Missing Link for Your Gut Health, GLP-1 Use, & Metabolism

If you’re taking a GLP-1 medication like Ozempic® or Mounjaro®, you’ve likely experienced the shift in appetite, energy, and digestion that comes with it. But what many women don’t realize is that your gut microbiome plays a critical role in how your body responds to weight loss medications and whether your results are sustainable.

That’s why I often recommend Pendulum’s clinical-grade probiotics, available through Fullscript, as part of a holistic wellness plan for women over 40. These aren’t your average grocery-store probiotics. They’re microbiome-specific formulas containing unique strains that support:

Blood sugar balance
GLP-1 production
Gut barrier health
Metabolic function

Let’s explore why the gut is so central to GLP-1 effectiveness—and how Pendulum’s probiotic formulas may help bridge the gap.

The Gut-GLP-1 Connection

GLP-1 (glucagon-like peptide-1) is a naturally occurring hormone that’s secreted in the gut. It regulates insulin, reduces appetite, and slows digestion, all of which support weight loss and metabolic function. But what fuels your body’s natural GLP-1 production? Certain gut bacteria. Studies have shown that strains like Akkermansia muciniphila and Clostridium butyricum are involved in:

GLP-1 release and glucose metabolism
Gut barrier protection
Reducing insulin resistance and inflammation

These microbes often decline with age, stress, poor diet, or antibiotic use, especially in women over 40. That’s where targeted probiotics come in.

🧬 Want to support your gut while on or after GLP-1 medications? Click here to shop Pendulum products on Fullscript

Shop Pendulum Products on Fullscript

Why I Trust Pendulum Probiotics

As a nurse practitioner and holistic nutrition weight loss coach, I’m cautious about what I recommend. Pendulum’s formulations are clinically tested, science-backed, and manufactured with care. Here are the ones I suggest most:

✅ Metabolic Daily

A foundational probiotic designed to support gut lining, microbial diversity, and mild metabolic support. Perfect for beginners or those easing into microbiome repair.

✅ Metabolic Daily Pro

Includes the signature Akkermansia strain plus butyrate-producing microbes for targeted support of insulin sensitivity and GLP-1 production. Ideal for women on or tapering off GLP-1s.

✅ GLP-1 Probiotic Pro

Pendulum’s most direct formula to support the GLP-1 hormone pathway and metabolic regulation. Recommended for clients actively transitioning off medication or experiencing rebound appetite.

✅ Glucose Control Pro

Contains clinically tested strains shown to reduce A1c and improve post-meal glucose response. A smart companion to any low-carb or insulin-conscious eating pattern.

💊 These are practitioner-grade probiotics available only through licensed dispensaries. Click here to access my Fullscript portal.

Click Here for Pendulum Products at Fullscript

Who Should Consider These Probiotics?

Women over 40 on or transitioning off GLP-1s
Those with prediabetes, PCOS, or metabolic resistance
Women struggling with digestion, constipation, or bloating
Anyone who’s plateaued in their weight loss or feeling “stuck” despite best efforts

If your gut isn’t happy, it’s hard to maintain progress—no matter how clean you eat or how consistent you are.

How to Use Probiotics in Your Weight Loss Journey

Start simple: Begin with Metabolic Daily or Metabolic Daily Pro if you’re new to probiotics.
Take consistently: Results build with daily use. Take with or after food.
Track your progress: Use a journal or checklist to notice changes in digestion, energy, mood, or sugar cravings.
Layer with support: Pair your probiotics with coaching, hydration, balanced meals, and realistic goals.

At Ample Health & Wellness, I help women use tools like this in an integrated way and not just as one more pill in the cabinet.

Real Talk: One of My Clients Said…

“I didn’t know how much my gut was affecting everything until I added the right probiotic. Within a few weeks, my bloating went down, my sugar cravings dropped, and I felt like my body was finally cooperating again.”

That’s the power of restoring your internal foundation. Pendulum isn’t a quick fix, but it can be a lasting piece of your healing journey.

Final Thoughts: Don’t Skip the Gut

If you’re on a wellness journey, don’t overlook your microbiome. Supporting your gut can help regulate blood sugar, reduce weight regain, improve digestion, and restore energy. That’s why I trust Pendulum, and why I’m proud to offer their clinical-grade products through my Fullscript dispensary.

📦 Click here to browse the full Pendulum probiotic collection now

Browse Pendulum Products at Fullscript

References:

Cani, P. D., & de Vos, W. M. (2017). Next-generation beneficial microbes: The case of Akkermansia muciniphila. Frontiers in Microbiology, 8, 1765. https://doi.org/10.3389/fmicb.2017.01765
Chambers, E. S., Viardot, A., Psichas, A., Morrison, D. J., Murphy, K. G., Zac-Varghese, S. E., … & Frost, G. (2015). Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance, and adiposity. Gut, 64(11), 1744–1754. https://doi.org/10.1136/gutjnl-2014-307913
Ghosh, S. S., Wang, J., Yannie, P. J., & Ghosh, S. (2021). Intestinal barrier dysfunction, LPS translocation, and disease development. Journal of Endocrinology, 251(3), R21–R39. https://doi.org/10.1530/JOE-21-0183